The application of nonionic surfactant and nonionic surfactant formulation in the silicone oil emulsion was studied. Uniform design and optimization soft-ware were used in design of the emulsifier formula and optimization of the experiment results. The synergic effects between the surfactants were investigated. The optimum [KG*4]formula [KG*4]was got. The nonionic surfactant [KG*4]and [KG*4]nonionic [KG*4]surfactant [KG*4]in [KG*4]the [KG*4]formula [KG*4]have [KG*4]synergic [KG*4]effect. [KG*4]The [KG*4]optimum [KG*4]formula [KG*4]of [KG*4]the [KG*2/3]mass [KG*2/3]ratio [KG*4]are w(X1)30.14%, w(X2)23.69%, w(X3)22.45%, w(X4)13.05%, w(X5)10.67%. The silicone oil emulsion is prepared and not stratified at the 3 000 r/min by centrifugating 30 min.